Factory Supply High quality/High cost performance Pharmaceutical Intermediate Anecortave Acetate CAS 7753-60-8

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Product origin: Shenzhen, Guangdong, China
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Description
Factory Supply High Quality Pharmaceutical Intermediate Anecortave Acetate CAS 7753-60-8
 
Product Name:Anecortave Acetate
Synonyms:[2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate;17-alpha,21-dihydroxypregna-4,9(11)-diene-3,20-dione21-acetate;17-Hydroxypregna-4,9(11)-diene-3,20-dione-21-acetate;anecortave acetate;Anacorta acetate;Pregna-4,9(11)-diene-17-ol-3,20-dione-21-acetate;17-ALPHA-HYDROXY-3,20-DIOXOPREGNA-4,9(11)-DIENE-21-YL ACETATE;21-Acetoxy-17-hydroxypregna-4,9(11)-diene-3,20-dione
CAS:7753-60-8
MF:C23H30O5
MW:386.48
EINECS:231-812-5
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
Mol File:7753-60-8.mol
 
 
Anecortave Acetate Chemical Properties
Melting point 230-234°C
alpha D +117° (c = 1.0 in CHCl3); D22 +124° (c = 1.04 in CHCl3).
Boiling point 551.8±50.0 °C(Predicted)
density 1.23±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Chlor-oform (Slightly), Meth-anol (Slightly)
pka12.47±0.60(Predicted)
form Solid
color Off-White to Beige

Description
Anecortave acetate, an angiogenesis inhibitor, was launched in Australia by Alcon for the treatment of age-related macular degeneration (AMD). AMD is the leading cause of untreatable blindness among people aged 65 to 74 years in the U.S. Worldwide, approximately 20 to 25 million people suffer from AMD, a disease that until recently was untreatable. Anecortave, an angiostatic steroid, down-regulates the expression MMP-2 and -9 to exert its antiangiogenic effects.

Uses: As an angiostatic steroid, Anecortave Acetate can be used in treatment of macular degeneration.





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