Naproxen sodium is a non-steroidal anti-inflammatory analgesic drug which is more tolerable to human, belonging to the phenylpropionic acid compounds. It plays anti-inflammatory effect by inhibiting prostaglandin synthesis.It is absorbed rapidly after oral administration and the plasma reached the peak concentration within 2 to 4 hours. Food has little effect on the rate of absorption. Naproxen and plasma protein are highly binded(99%); the plasma concentration is between 23~40mcg/ml. The metabolic process is demethylation and then combining with glucuronide; the elimination half-life is 12 to 15 hours, mainly excreted by the urine. Clinical application is to relieve a variety of mild to moderate degree of pain, such as tooth extraction and other postoperative pain, primary dysmenorrhea and headache. It is also used for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendinitis, bursitis and acute gouty arthritis; it also plays a role in arthritis pain, swelling and activity restricted symptom. Psoriatic arthritis and Reiter's syndrome can also be treated with this product. Compared with ibuprofen, fenoprofen, aspirin, sulindac and indomethacin, the symptom relief effect was similar, but the incidence and severity of adverse reactions in the gastrointestinal and neurological systems were low. In addition, this product is also the same as aspirin which can inhibit platelet aggregation and prolong bleeding time; but the effect is reversible, and can be restored after stopping. Naproxen sodium and plasma protein binding rate is high (99%), and other protein-binding drugs can be replaced by its joint out. Therefore, the acceptance of these drugs (such as oral anticoagulants, sulfonylurea, hydantoins) people should observe the interaction effects. At the same time the application of probenecid, naproxen can increase the plasma concentration, half-life period. Magnesium hydroxide, aluminum can make this product absorption rate slightly lower; sodium bicarbonate can make it higher.
Uses: Naproxen (Aleve, Anaprox) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively Uses: A cyclooxygenase inhibitorNaproxen sodium acts as a nonselective inhibitor of Cox-1 and Cox-2. It serves as an anti-inflammatory agent with analgesic and antipyretic properties. Further, it is used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea and acute gout. Uses: An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory.
Why Choose Us? 1.OEM/ODM Available. 2. Raw materials from chinese origin 3. Best quality in your requirement 4. Competitive price in china market 5 Fast delivery and free sample for your evaluation.Stock availability 6.Door to door shipping service is available. 7. Professional documents for your custom clearance. 8. Full experience of large numberscontainers loading in chinese sea port 9. Packing with pallet or as buyer's special request 10. Best after-service after shipment
Shenzhen Changhua Biotechnology Co., Ltd. A leading supplier of fine chemical in China, is located in Shenzhen. The unique geographical conditions of Shenzhen are favorable for transportation.
The company invests large fund and brains to R&D department to research fine chemical, biochemical, pharmaceutical & its intermediates products that fit the demand of the market. High level research group, advanced apparatus and good scientific atmosphere ensure the quality.
According to the GMP standard, the company has built 10000 m2 plant with the advanced equipment. The factory has a complete Q. A. & Q. C. System. We own several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and UV spectrophotometer to analyze and control the products. The company has gotten the approval of SGS to be as audited supplier. We have the authority of export and import. Our products are sold both in the domestic and international market and highly recommended by our clients. In order to develop the market further, we are eager to cooperate with the manufactory and trading company around the globe to make a prosperous future.
Complaint
