Collagen Sheet Dressing in Burn and Chronic Wounds

Collagen Dressing are derived from corium and consist of type I bovine collagen. Type I collagen is necessary for the management of wounds, because it acts as a material that keeps wounds moist, absorbing exudate from them. It has been demonstrated that intact Type I Collagen binds to several proteases and inflammatory cytokines that are in excess in exudates from chronic wounds, including neutrophil elastase, MMP-2, Interleukin IL -6, IL-8 and IL-1β.

In addition, collagen is a major abundant fibrous protein in the extracellular. Collagens, which constitute the primary structural element of the ECM, provide tensile strength, regulate cell adhesion, support chemotaxis and migration, and direct tissue development, leads to a significant increase in the number of fibroblasts, increases the deposition of guided and organized collagen fibers, assists in the assimilation and bioavailability of fibronectin, helps maintain the chemical microenvironment and thermostatic wound, and inhibits or deactivates excessive matrix metalloproteinases.