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GLP-1/Gip/Glucagon Agonist Retatrutide Ly3437943 10mg 12mg 24% Weight Loss 2381089-83-2
GLP-1/Gip/Glucagon Agonist Retatrutide Ly3437943 10mg 12mg 24% Weight Loss 2381089-83-2
GLP-1/Gip/Glucagon Agonist Retatrutide Ly3437943 10mg 12mg 24% Weight Loss 2381089-83-2
GLP-1/Gip/Glucagon Agonist Retatrutide Ly3437943 10mg 12mg 24% Weight Loss 2381089-83-2
GLP-1/Gip/Glucagon Agonist Retatrutide Ly3437943 10mg 12mg 24% Weight Loss 2381089-83-2
GLP-1/Gip/Glucagon Agonist Retatrutide Ly3437943 10mg 12mg 24% Weight Loss 2381089-83-2

GLP-1/Gip/Glucagon Agonist Retatrutide Ly3437943 10mg 12mg 24% Weight Loss 2381089-83-2

Min.Order: 50
Product origin: Hangzhou, Zhejiang, China
Infringement complaint: complaintComplaint
US$ 29.8 ~ 35.5

Description

Description

  • Retatrutide is a novel triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide inhibits human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively and mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively. It is an important tool for obesity research.
  • Retatrutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GIP receptor (GIPR) or the GLP-1R.
  • Retatrutide is a synthetic peptide with glucose-lowering effects. It is an antidiabetic agent against type 2 diabetes (T2D), stimulating insulin and suppressing glucagon secretion in a glucose-dependent manner.
  • Retatrutide was also shown to delay gastric emptying, lower fasting and postprandial glucose concentration, decrease food intake and reduce body weight in patients with type 2 diabetes.
More Information
Product Details
SynonymsLY3437943; GGG Tri-agonist
Product TypeChemical
Properties
Formula

C221H342N46O68

MW4731.4
Sequence

H-Tyr-(Aib)-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-(α-Me-Leu)-Leu-Asp-Lys-(diacid-C20-gamma-Glu-(AEEA)-Lys)-Ala-Gln-(Aib)-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

CAS2381089-83-2 (free acid)
Source/Host ChemicalsSynthetic.
Purity Chemicals≥99% (HPLC)
AppearanceWhite lyophilized powder.
SolubilitySoluble in water (5mg/ml).
IdentityDetermined by MS.
Other Product Data

Water Content (by Karl Fischer): ≤7%

Shipping and Handling
ShippingAMBIENT
Short Term Storage+4°C
Long Term Storage-20°C
Handling AdviceKeep cool and dry.
Use/StabilityStable for at least 1 year after receipt when stored at -20°C.
Documents
MSDSInquire
Product Specification Sheet
DatasheetInquire

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