Complaint
The neurotransmitter dopamine is widely distributed in the central nervous system, brain tissue and body fluids of mammals, and its trace determination is of great significance for neurophysiology, exercise physiology, pathology, clinical medicine and disease diagnosis. Dopamine (DA) is the most important catecholamine, which plays a key role in the Chemicalbook of the central nervous system and kidney system. An imbalance in dopamine production in the body can lead to heart disease, schizophrenia and Parkinson's disease. Dopamine hydrochloride is water-soluble and can enhance myocardial contractility and increase blood output. It is widely used in shock syndrome caused by myocardial infarction, trauma, endotoxin sepsis, heart surgery, renal failure, congestive heart failure and so on.
Dopamine hydrochloride can be used for various types of shock, hypotension. Including toxic shock, cardiogenic shock, hemorrhagic shock, central shock, especially for patients with renal dysfunction Chemicalbook, reduced cardiac output, increased peripheral vascular resistance, and replenalized blood volume. It can also treat cardiac insufficiency and acute renal insufficiency.
Dopamine is the precursor of norepinephrine biosynthesis, as one of the central transmitters, has the effect of excitating β-receptor, A-receptor and dopamine receptor, excitating cardiac β-receptor can increase myocardial contractility and cardiac output. Excitatory dopamine receptors and alpha-receptors cause dilation of kidney, mesentery, coronary artery, and cerebrovascular vessels, and increase Chemicalbook blood flow. It has mild contractile effect on peripheral blood vessels and increases arterial blood pressure. The prominent effect of this drug is to increase renal blood flow and glomerular filtration rate, thus promoting the increase of urine volume and urinary sodium excretion. It is clinically used for various types of shock, especially for shock with reduced systolic force and renal insufficiency.
1.Name: Dopamine Hcl /Dopamine Hydrochloride
2.CAS: 62-31-7
3.EINECS: 200-527-8
4.MF: C8H11NO2.HCl
5.MW: 189.64
6.Chemical Name: 4-(2-aminoethyl)-1, 2-pyrocatechol hydrochloride
7.Molecular formula: C8H11NO2·HCL
Test Item | Analysis Specification | Result |
Description | White or almost white, crystalline power | Conform |
Solubility | Freely soluble in water, soluble in ethanol (96%),sparingly soluble in acet one and in meth ylene chlor ide | Conform |
Identification A | Absorption maximum at 280nm | 279.4 nm |
B | IR Should be identical with contrast | Conform |
C | It gives reaction (a) of color | Conform |
D | It gives reaction (a) of color | Conform |
E | It gives reaction (a) of chlorides | Conform |
Appearance of solution | The solution is clear and not more intensely colored than references solution B6 or Y6 | Conform |
Acidity or alkalinity | Should be conform | Conform |
Related substance | Total of other impurity NMT0.25%(TLC) | Conform |
Heavy metals | NMT 20 ppm | Conform |
Loss on drying | NMT 0.5% | 0.22% |
Sulphated ash | NMT 0.2% | Conform |
Residual Solvents | Should be conform | Conform |
Assay(anhydrous substance) | 98.0%~102.0% | 99.6% |
Conclusion | Conform to BP2007 Standard | |
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