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Medication Pearl of the Day: Semaglutide (Ozempics)

Indication: Semaglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus and to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes mellitus and established cardiovascular disease.

 

Insight:

• Dosing: Start at 0.25 mg once weekly. After 4 weeks, increase the dose to 0.5 mg once weekly. If after at least 4 weeks additional glycemic control is needed, increase to 1 mg once weekly.
• Dosage forms: Injection 2 mg/1.5 mL (1.34 mg/mL) available in a single-use pen that delivers 0.25 mg or 0.5 mg per injection. The single-use pen delivers 1 mg per injection. Injection 4 mg/3 mL (1.34 mg/mL) available in a single-use pen that delivers 1 mg per injection.
• Adverse events: The most common adverse reactions, reported in ≥5% of patients treated with semaglutide are nausea, vomiting, diarrhea, abdominal pain, and constipation
• Mechanism of action: Semaglutide is a GLP-1 analogue with 94% sequence homology to human GLP-1. Semaglutide acts as a GLP-1 receptor agonist that selectively binds to and activates the GLP-1 receptor, the target for native GLP-1.
• Manufacturer: Novo Nordisk

Looking for a weight loss treatment that really works? Ozempics is a once-daily, self-injectable pen that can help you lose weight and keep it off for good. Learn more about Ozempics Weight loss pens work and how it can help you reach your weight loss goals.

Ozempics is an injectable medication that helps promote weight loss by suppressing appetite and boosting metabolism.  is a GLP-1 analogue, which means it works by mimicking the effects of the hormone GLP-1. GLP-1 is responsible for regulating appetite and metabolism, and when levels of GLP-1 are increased, people tend to eat less and lose weight.

Ozempics is approved for use in adults with a BMI of 30 or above, or adults with a BMI of 27 or above who have other weight-related health conditions such as type 2 diabetes or high cholesterol. is not for use in children.

Ozempics is injected under the skin, typically once a day at the same time each day. The recommended starting dose is 0.25 mg, but this may be increased over time based on individual response.