Complaint
| Functions and Application of Hyaluronic acid | ||
| Grade | Functions | Application |
| Food grade | Restore skin moisture, improve skin health condition; Antioxidation; Improve joint health; Improve bowel function and protect gastric mucosa. | Common food: beverage, jelly, dairy products etc., Healthy food: usually in combination with Collagen, Vitamins, Chondroitin Sulphate, to make tablets, capsules or oral liquid. |
| Cosmetic Grade | Lubricating and film-forming, moisturizing, preventing skin damage, thickening and keeping emulsion stable; Nourishing the skin, long-lasting moisturizing; Trans-dermal absorption, deep hydrating, anti-ageing, repairing skin damage. | Skin care products:cream, emulsion, essence, lotion, gel, facial mask, etc.; Beauty products: lipstick, eye shadow, foundation, etc.; Cleansing products: facial cleanser, body wash, etc.; Hair products: shampoo, hair conditioner, styling gel, hair restorer, etc. |
| Eye Drop Grade | Lubricating, moisturizing, improving efficacy of drugs, relieving dry eye syndrome, and promote healing of corneal and conjunctiva injury; Wound healing; Repairing damaged mucous membrane or cartilage, etc. | For parenteral preparations or oral preparations not including intra-articular and intra-ocular preparations. It can be used in eye drops, contact lens solutions, topical preparations for wound or burn healing, medical lubricants etc. |
| Injection Grade | Protecting corneal endothelium; Lubricating, repairing damage cartilage, inhibition of inflammation; | For parenteral preparations including intra-articular and intra-ocular preparations, such as intra-articular injections, intradermal injections for aesthetic correction, anti-adhesive products, etc. |
| Test Item | Test standards (EP7.0) |
| Appearance | White powder or granule |
| Sodium hyaluronate | ≥95.0% |
| Glucuronic acid | ≥46.0% |
| Solubility | Soluble in water |
| Appearance of solution | A600nm≤0.01 |
| Nucleic Acid | A260nm≤0.5 |
| PH | 5.0~8.5 |
| Molecular weight | ≤0.8~1.5 Million Dalton |
| Protein | ≤0.01% |
| Loss on drying | ≤10.0% |
| Residue on ignition | ≤20.0% |
| Chlorides | ≤0.5% |
| Heavy metal (as Pb) | ≤10mg/kg |
| As | ≤2mg/kg |
| Nitrogen | 3.0%~4.0% |
| Bacteria counts | ≤10 CFU/g |
| Molds&Yeasts | ≤10 CFU/g |
| Salmonella | Negative |
| Staphylococcus aureus | Negative |
| Pseudomonas aeruginosa | Negative |
| Hemolysis | Negative |
| Viable Hemolytical Streptococci | Negative |
| Endotoxin level | ≤0.5EU/mg |
