Hot Selling Sodium Bicarbonate Injection 0.5g 10ml

Indications
1. Water loss caused by various reasons, including hypotonicity, isotonicity and hypertonicity.
2. In hypertonic nonketotic coma, the application of isotonic or hypotonic sodium chloride can correct dehydration and hypertonic state.
3. Externally use normal saline to flush eyes and wash wounds.
4. Water bladder for obstetrics to induce labor.

Dosage
1. Hypertonic water loss: The osmotic concentration of brain cells and cerebrospinal fluid increases in patients with hypertonic water loss. If the sodium concentration and osmotic concentration of plasma and extracellular fluid drop too quickly, brain edema may be caused. Therefore, it is generally believed that within 48 hours of the beginning of treatment, plasma sodium concentration does not drop more than 0.5 mmol/L per hour. If the patient has shock, sodium chloride injection should be given first, and the colloid should be supplemented as appropriate. After the shock is corrected, serum sodium>155mmol/L, plasma osmotic concentration>350mOSm/L, 0.6% hypotonic sodium chloride injection can be given. When the plasma osmotic concentration is <330mO5m/L, switch to 0.9% sodium chloride injection. The total amount of fluid replacement is calculated according to the following formula as a reference:

Generally, half of the amount will be replenished on the first day, and the remaining amount will be replenished in the next 2 to 3 days, and adjusted according to the cardiopulmonary and kidney function.

2. Hypotonic water loss: In severe hypotonic water loss, the solute in brain cells is reduced to maintain cell volume. If the treatment causes the plasma and extracellular fluid sodium concentration and osmotic concentration to rise rapidly, it can cause brain cell damage. It is generally believed that when blood sodium is lower than 120mmol/L, the rate of increase in blood sodium will be 0.5mmol/L per hour and not more than 1.5mmol/L per hour.

When the blood sodium is lower than 120mmol/L or symptoms of the central nervous system occur, 3%~5% sodium chloride injection can be instilled slowly, and it is generally required to increase the blood sodium concentration to more than 120mmol/L within 6 hours. Sodium supplementation (mmol) = [142-actual blood sodium concentration (mmol/L)] × body weight (Kg) × 0.2. When the blood sodium rises to above 120~125mmol/L, you can switch to isotonic solution or isotonic solution and add hypertonic glucose injection or 10% sodium chloride injection as appropriate.

Adverse reactions

1. Too much or too fast infusion can cause water and sodium retention, causing edema, increased blood pressure, increased heart rate, chest tightness, dyspnea, and even acute left heart failure.

2. Too much or too fast hypotonic sodium chloride can cause hemolysis and cerebral edema.

Precautions 

1. Use with caution in the following situations:

(1) Edema diseases, such as nephrotic syndrome, liver cirrhosis, ascites, congestive heart failure, acute left heart failure, cerebral edema and idiopathic edema, etc.;

(2) Patients in the oliguria stage of acute renal failure and chronic renal failure with reduced urine output and poor response to diuretics;

(3) Hypertension;

(4) Hypokalemia.

2. According to clinical needs, check the serum sodium, potassium, chloride ion concentration; blood acid-base concentration balance index, kidney function, blood pressure and heart and lung function.

Children's Medication

The amount and speed of rehydration should be strictly controlled

Medication for elderly patients

The amount and speed of rehydration should be strictly controlled

medicine interactions

1. When used as a drug solvent or diluent, the compatibility of drugs should be noted;

2. It can cause hypernatremia and hypokalemia, and can cause loss of bicarbonate.