Complaint
| Product Name: | Mirabegron |
| CAS: | 223673-61-8 |
| MF: | C21H24N4O2S |
| MW: | 396.51 |
| EINECS: | 800-126-3 |
Betanis (Mirabegron) was approved in July 2011 by the Japanese Ministry of Health, Labour, and Welfare for the treatment of urgency, urinary frequency, and urinary urge urinary incontinence associated with overactive bladder (OAB). Mirabegron is synthesized by coupling 4-nitrophenethyl amine to (R)-2-hydroxy-2-phenylacetic acid. The resulting amide is reduced to an amine. The nitro group is then reduced and the resulting is coupled to 2-(2-aminothiazol-4-yl) acetic acid to give mirabegron. Mirabegron has an EC50 of 22 nM (intrinsic activity=0.8) for β3-AR with no detectable activity for β1- andβ2-AR (EC50>10,000 nM). In an anesthetized rat rhythmic bladder contraction model in which bladder contractions are induced by saline, mirabegron at 3 mg/kg iv decreased the frequency of rhythmic bladder contraction without suppressing contraction amplitude. These data suggest that the activation of β3-AR increases bladder capacity without influencing the frequency of bladder contraction.
Uses
Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
A potent bladder relaxant compound.
Potent bladder relaxant and reagent for diabetes remedy.;Labeled Mirabegron, intended for use as an internal standard for the quantification of Mirabegron by GC- or LC-mass spectrometry.
Packaging Details
25kg carton drum (32cm*58cm)or 1kg foil bag (10cm*15cm) or by request of clients
Port:TIANJIN
Lingding Biotechnology Co., Ltd. is a professional business company ,that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise, The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.
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![CAS 223673-61-8 Mirabegron / Mirabegron (YM 178) / Ym 178 / 2-Amino-N-[4-[2-[[ (2R) -2-Hydroxy-2-Phenyl-Ethyl]Amino]-Ethyl]Phenyl]-4-Thiazoleacetamide](https://img.china-sups.com/ecc5e25d46cd0b6f09fa649582720800.jpg)
