Kava Kava Extract Functions: Kava is a type of pepper tree that grows in the South Pacific Islands (Tonga, Samoa, Fiji, Vanuatu) and Tahiti. Kava root has been used as a traditional medicine in the South Pacific Islands for hundreds of years. The main pharmacological action of kava extract is the complex synergistic effect of various Kavalactones. Like many other medicinal plants, kava contains not only a is the main active, but a complex mixture of different molecules called kavalactones, which include tascapillin, dihydrotascapillin, yangonin, and desmethoxyyangonin. Kava's active principal ingredients kavalactones, of which at least 15 have been identified and are all considered psychoactive. Only six of them produce noticeable effects, and their concentrations in kava plants vary. Different ratios can produce different effects. Desmethoxyyangonin, one of the six major kavalactones, is a reversible MAO-B inhibitor (Ki 280 nM) and is able to increase dopamine levels in the nucleus accumbens. This finding might correspond to the slightly euphoric action of kava. Kava is used to calm anxiety, stress, and restlessness, and treat sleep problems (insomnia). It is also used for attention deficit-hyperactivity disorder (ADHD), epilepsy, psychosis, depression, migraines and other headaches, chronic fatigue syndrome (CFS), common cold and other respiratory tract infections, tuberculosis, muscle pain, and cancer prevention. Some people use kava for urinary tract infections (UTIs), pain and swelling of the uterus, venereal disease, menstrual discomfort, and to arouse sexual desire. Kava is applied to the skin for skin diseases including leprosy, to promote wound healing, and as a painkiller. It is also used as a mouthwash for canker sores and toothaches.
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