Analysis item | Standard | Analysis results |
Appearance | White to light yellow crystalline powder | Off white powder |
Identification | IR spectra is consistent with CRS | Conforms |
Loss on drying | ≤0.5% | 0.002 |
PH | 7.0~9.0 | 8 |
Residue on ignition | ≤0.2% | 0.0001 |
Total impuriries | ≤0.5% | conforms |
Assay | 99.0%~101.0% | 0.998 |
Function:
Sodiumdichloroacetate (DCA, dichloroacetic acid, biochloracetic acid, BCA) is a specific inhibitor of pyruvatehydrogenasekinase (PDK). The IC50 values for PDK2 and PDK4 are 183 and 80, respectively μ M; It can inhibit na+-k+-2cl-cotransporter and mitochondrial potassium channel axis. Sodiumdichloroacetate can increase the production of reactive oxygen species, cause cancer cell apoptosis, and inhibit tumor growth.
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