Pharma API Lappaconitine Hydrobromide Used in Cardiovascular CAS No.: 97792-45-5

Product Description:

Lappaconitine hydrobromide, a diterpene alkaloid, is a drug for the treatment of cardiac arrhythmias. IC50 value: Target: A natural product for anti-cardiac arrhythmias In vitro: Lappaconitine hydrobromide was found to exert an inhibitory effect on inward tetrodotoxin-sensitive sodium currents without changing their voltage dependence [1]. In vivo: The effect of Lappaconitine hydrobromide on aconitine--induced arrhythmias is due to modulation of genes encoding Na(+)-, K(+)-, Ca(2+)-channels, conducting ionic currents (I(Na), I(to), I(Ks), I(K1), I(CaT)), which are involved in the formation of different phases of the action potential [2]. Lappaconitine hydrobromide was found to be beneficial both in ventricular and supraventricular premature beats. Oral allapinine usually showed its effect 40-60 minutes following its administration, its maximum action being 4-5 hours later, its duration was some 8 hours. The optimal dose of the drug amounted to 75 mg/day [3].
Uses, benefits, Side Effects
   This product has local anesthesia, cooling, antipyretic and anti-inflammatory effect
   It also has antiepileptic, anti-tumor, anti-bacterial, anti-oxidation and immunomodulation effects. Hypericarbromide can control epileptic activity by inhibiting hippocampal neuronal activity.

Application
For more than moderate pain,It is a non-addictive analgesic with strong analgesic effect
Quality Control: 
The testing center of our company is equipped with ULTRAVIOLET room, atom room, gas room, high efficiency liquid room, balance room, high temperature room, chemical room, bacteria examination room, stability laboratory, sample room and central laboratory. Coordinated, comprehensive, systematic and standardized testing of all raw materials, production water, intermediates and finished products to ensure that unqualified raw materials are not put into storage. Disqualified intermediates do not flow into the next process. Nonconforming finished products will not be shipped.

Package:
1kg,5kg in aluminum bag. 25kg per drum.
Storage:
Store at below 25ºC temperature and away from light.
Shipping:
Bulk goods ship by sea or air. Small quantity shipped via FedEx, DHL and others courier.

Customization Service
R&D and Production: We specializes in the development of functional materials and has provided a number of development and improvement solutions.
Granular Production: Our granulation and superfine pulverization can improve bulk density to filling capsules and tablets. and increase water solubility.
Blending and Mixing