Description
Medical polyethylene glycol is also called PEO. Linear polyether obtained by ring-opening polymerization. The main uses in the biomedical field are as follows:
1. Contact lens solution. The viscosity of polyethylene glycol aqueous solution is sensitive to shear rate and bacteria are not easy to grow on polyethylene glycol.
2. Synthetic lubricant. Condensation polymer of e-o and water. It is the ointment matrix for preparing water-soluble drugs, and can also be used as the solvent of such insoluble drugs as acetylsalicylic acid, nimodipine, etc. for the preparation of injection.
3. The carrier of drug release and immobilized enzyme. Applying polyethylene glycol aqueous solution to the outer layer of the pill can control the drug diffusion in the body to improve the efficacy.
4. Surface modification of medical polymer materials. The adsorption, interception and grafting of amphiphilic copolymer containing polyethylene glycol on the surface of medical polymer materials can improve the biocompatibility of medical polymer materials in contact with blood.
5. Make alkanol contraceptive film.
6. Make hydrophilic anticoagulant polyurethane.
7. Polyethylene glycol 4000 is an osmotic laxative, which can increase the osmotic pressure in the intestinal cavity, absorb water, soften and increase the volume of stool, and promote the intestinal peristalsis and defecation.
8. Denture fixative. Polyethylene glycol is used as a component of denture fixative due to its non-toxic and gelatinous properties.
9. PEG 4000 and PEG 6000 are commonly used to promote cell fusion or protoplast fusion and help organisms (such as yeast) to absorb DNA during transformation. PEG can absorb water in solution, so it is also used to concentrate solution.
10. In the experiment of studying protein molecules, the crowding environment in vivo can be simulated to verify the effect of crowding environment on protein structure.
| USP/EP |
| PEG20000 |
| PEG15000 |
| PEG10000 |
| PEG8000/6000/4000 |
| PEG3000 |
| PEG1500 |
| PEG1000 |
Complaint
