Prazi-quantel was effective in killing adult schistosoma japonicum. Its insecticidal mechanism, from the molecular level, is that prazi-quantelone rapidly destroys the Ca2+ balance in the worm, on the one hand, it leads to the activity of the worm and muscle contracture, so that the schistosoma parasitic on the portal system can not attach to the blood vessel wall and be carried to the liver by the blood flow (liver migration), and thus be damaged. The other is that Chemicalbook causes damage to the syncytial cortex of schistosoma. In addition to affecting the absorption, excretion and secretion functions of schistosoma, resulting in the disorder of glucose metabolism and enzyme system, the epitopes of the body surface of schistosoma are exposed, which can be recognized by the host immune system and attract a large number of inflammatory cells such as neutrophils, eosinophils and macrophages to gather the schistosoma Attack around.