Adipotide is a synthetic peptide that possesses anti-obesity properties. this peptide particularly targets and destroys specific proteins that constitute the surface of blood vessels that support white fat (adipose) tissue hence interfering with the supply of blood to the fat cells and resulting in their adoptosis (reabsorption and metabolization). Adipotide was initially referred to as Prohibitin-TP01 (Prohibitin-Targeting Peptide 1). It is a peptidomimetic that was synthesized by American scientists as a potential therapeutic drug for obesity and its amino acid sequence is CKGGRAKDC-GG-D(KLAKLAK)2. Adipotide has a molecular formula of C111H204N36O28S2. Peptidomimetics are tiny protein like chains that imitate peptides. It is an experimental drug for weight loss. It was developed in a way that enables it to bind to two receptors, prohibitin and ANXA2 which are found in blood vessels that support white adipose tissue. In rat and monkey based experiments, Adipotide has been shown to bring about rapid weight loss in both mice and rhesus monkeys. In general, Adipotide has been observed to bring about weight loss by reducing fat tissue especially in the abdominal region), rapid metabolic changes, and decreased food intake.
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