INDICATIONS
1. Edematous diseases including congestive heart failure, liver cirrhosis, renal diseases (nephritis, nephropathy and acute and chronic renal failure due to various causes), especially when the application of other diuretics is not effective, the application of this class of drugs may still be effective. Combined with other drugs to treat acute pulmonary edema and acute cerebral edema, etc.
2. Hypertension in the step therapy of hypertension, not as the first choice for the treatment of primary hypertension, but when the thiazide drugs are not effective, especially when accompanied by renal insufficiency or hypertensive crisis, this class of drugs is particularly suitable.
3. Prevention of acute renal failure is used for various causes of inadequate renal perfusion, such as water loss, shock, poisoning, anesthesia accidents and circulatory insufficiency
Adverse reactions
Commonly associated with water and electrolyte disorders, especially in high doses or long-term application, such as postural hypotension, shock, hypokalemia, hypochlorhydria, hypochlorhydria, hypochlorhydria alkalosis, hyponatremia, hypocalcemia, and related thirst, weakness, muscle aches, and cardiac arrhythmias.
Rarely, there are allergic reactions (including rash, interstitial nephritis, and even cardiac arrest), blurred vision, xanthopsia, photosensitivity, dizziness, headache, poor appetite, nausea, vomiting, abdominal pain, diarrhea, pancreatitis, muscle tonus, bone marrow suppression leading to granulocytopenia, thrombocytopenic purpura and aplastic anemia, hepatic impairment, abnormal finger (toe) sensation, hyperglycemia, positive urine glucose, exacerbation of pre-existing aggravation of diabetes mellitus, hyperuricemia. Tinnitus and hearing impairment are most often seen with high doses of rapid intravenous injection (doses greater than 4-15 mg per minute) and are mostly transient and rarely irreversible, especially when applied concomitantly with other ototoxic drugs. In hypercalcemia, it can cause kidney stones. This drug has also been reported to aggravate idiopathic edema.
STORAGE
Store in a cool, dry & dark place.
Keep all medicines out of childen.
Support OEM/ODM | Yes |
Standard Available | CP,BP |
Documents | GMP,COPP,FSC,CTD |