What is Sodium Hyaluronate?
Grade | Specification | Functions | Applications | Notes |
HA-EP1.8 | 1.6~2.2 m³/kg;<0.05 IU/mg; 0.5~0.8 million Dalton | 1. Viscoelasticity, protecting corneal endothelium 2. Lubricating, viscoelasticity, Repairing damaged cartilage, inhibiting inflammation, pain relief, etc 3. Good biocompatibility and bio-degradability of HA and its derivatives | 1. Ophthalmic Viscosurgical Devices(OVD) 2. Intra-articular injections 3. Anti-adhesive products, dermal filler, scaffold materials in tissue engineering, etc | Contact Us |
HA-EP-N2.5 | 2.2~3.0 m³/kg;<0.04 IU/mg; 0.5~0.8 million Dalton | Contact Us | ||
HA-EP-N1.8 | 1.6~2.2 m³/kg; <0.04 IU/mg; 0.5~0.8 million Dalton | Contact Us | ||
HA-EP-N0.8 | 1.0~1.4m³/kg; <0.04 U/mg; 0.5~0.8 million Dalton | Contact Us |
Grade | Specification | Functions | Applications | Notes |
HA-EP3.0 | 2.7~3.6 m³/kg; <0.5 IU/mg; 0.5~0.8 million Dalton | 1. Lubricating, moisturizing, improving the efficacy of drugs, relieving dry eye syndrome, and promoting healing of corneal and conjunctival injury 2. Wound Healing 3. Drug or cell carrier/matrix 4. Repairing damaged mucous membranes or cartilage etc | 1. Eye drops, eye lotions, contact lens solutions, medical lubricants, etc 2. Topical preparations ( formulations of gel, film, etc.) 3. Eye drops, cell culture, etc 4. Oral pharmaceutical preparations | Contact Us |
Specification | Functions | Applications | Notes |
>1.5million Dalton | 1. A dense biological moisturizing film is formed on the skin surface, which is long-lasting moisturizing and anti-PM2.5 2. Good moisturizing and lubricating properties, slow-release, stable emulsification 3. Repair damaged and early-aged skin; water and soften the stratum corneum, lasting moisturizing, soft skin; Increase skin elasticity and delay skin aging; Promote the proliferation and differentiation of epidermal cells, scavenge oxygen free radicals 4. Transdermal absorption, deep moisturizing. Anti-aging, repair after sun | 1. Skin care products: creams, lotions, lotions, essences, gels, masks, etc 2. Cleaning products: facial cleanser, shower gel, etc 3. Hair products: shampoo, conditioner, hair restorer, hair spray, etc | Contact Us |
0.8-1.5million Dalton | Contact Us | ||
<0.1million Dalton | Contact Us | ||
<0.01million Dalton | Contact Us |
Specification | Functions | Applications | Notes |
>1.5million Dalton | 1. Regulate osmotic pressure, maintain tissue morphology, nourish cranial nerves 2.Protect gastric mucosa, lubricate lumen 3. Supplement HA in the body, maintain normal body function, and improve immunity 4. Promote cartilage repair, inhibit inflammation, and relieve soreness 5. Replenish eyeball moisture, and relieve dry, astringent, and itchy eyes 6. Replenish skin moisture, enhance skin elasticity, and reduce wrinkles | 1. Food additive 2. Dietary supplements | Contact Us |
0.8-1.5million Dalton | Contact Us | ||
<0.1million Dalton | Contact Us | ||
<0.01million Dalton | Contact Us |
The Function of Sodium Hyaluronate
Molecular Structure of Sodium Hyaluronate
Test Items | Specification | Test Result |
Appearance | White or almost white powder or granule | Complied |
PH(1% water solution) | 5.0~8.5 | 7.1 |
Transmittance | T550nm≥99.0% | 99.8% |
Absorbance | A280nm≤0.25 | 0.15 |
Loss on drying | ≤10.0% | 6.4% |
Glucuronic acid | ≥45.0% | 47.16% |
Sodium hyaluronate | ≥93.0% | 97.50% |
Molecular weight, Dalton | measured value | 2.0*106 Dalton |
Intrinsic viscosity | measured value | 29.6dL/g |
Kinematic viscosity | measured value | 64.6mm2/s |
Protein | ≤0.1% | 0.05% |
Heavy Metals | ≤20mg/kg | <10mg/kg |
Bacteria counts | ≤100cfu/g | Complied |
Mold & Yeast | ≤50cfu/g | Complied |
Staphylococcus aureus | Negative/g | Negative |
Pseudomonas aeruginosa | Negative/g | Negative |
Test Items | Specification | Test Result |
Appearance | White or almost white powder or granule | Complied |
PH | 6.0~8.0 | 6.7 |
Transmittance | T600nm≥99.0% | 99.8% |
Loss on drying | ≤10.0% | 6.4% |
Glucuronic acid | ≥44.5% | 47.2% |
Sodium hyaluronate | ≥92.0% | 97.6% |
Molecular weight, Dalton | measured value | 1.00*106 Dalton |
Intrinsic viscosity | measured value | 17.1dL/g |
The bulk density | measured value | 0.32g/cm3 |
The tap density | measured value | 0.49g/cm3 |
Protein | <0.1% | 0.05% |
Ash | ≤13.0% | <13.0% |
Heavy Metal(as Pb) | ≤10mg/kg | <10mg/kg |
Arsenic | ≤2mg/kg | <2mg/kg |
Bacteria counts | ≤100cfu/g | Complied |
Mold & Yeast | ≤50cfu/g | Complied |
Staphylococcus aureus | Negative/g | Negative |
Escherichia coli | Negative/g | Negative |
Salmonella | Negative/25g | Negative |
Test Items | Specification | Test Result |
Appearance | White or almost white powder or granule | Complied |
PH(1% water solution) | 5.0~8.5 | 7.0 |
Transmittance | T550nm≥99.0% | 99.8% |
Absorbance | A280nm≤0.25 | 0.17 |
Loss on drying | ≤10.0% | 7.4% |
Glucuronic acid | ≥45.0% | 47.21% |
Sodium hyaluronate | ≥93.0% | 97.6% |
Molecular weight, Dalton | measured value | 2.0*105 Dalton |
Intrinsic viscosity | measured value | 4.91dL/g |
Kinematic viscosity | measured value | 4.61mm2/s |
Protein | ≤0.1% | 0.05% |
Heavy Metals | ≤20mg/kg | <10mg/kg |
Bacteria counts | ≤100cfu/g | Complied |
Mold & Yeast | ≤50cfu/g | Complied |
Staphylococcus aureus | Negative/g | Negative |
Pseudomonas aeruginosa | Negative/g | Negative |
Test Items | Specification | Test Result |
Appearance | White or almost white, very hygroscopic powder or fibrous aggregate | Complied |
PH(1% water solution) | 5.0~8.5 | 7.0 |
Solubility | Sparingly soluble or soluble in water, practically insoluble in acetone and in anhydrous ethanol | Complied |
Identification | A. Infrared absorption spectrophotometry | Complied |
B. It gives reaction (a) of sodium | Complied | |
Loss on drying | ≤10.0% | 5.7% |
Sodium hyaluronate | ≥95.0% | 97.0% |
Appearance of solution | A600nm≤0.01 | Complied |
Nucleic acids | A260nm≤0.5 | Complied |
Molecular weight, Dalton | measured value | 10,000 Dalton |
Intrinsic viscosity | measured value | 0.19dL/g |
Protein | ≤0.1% | 0.06% |
Chlorides | ≤0.5% | Complied |
Iron | ≤80ppm | <80ppm |
TAMC | ≤100cfu/g | Complied |
Staphylococcus aureus | Negative/g | Negative |
Pseudomonas aeruginosa | Negative/g | Negative |
Test Items | Specification | Test Result |
Appearance | White or almost white powder or granule | Complied |
PH(1% water solution) | 5.0~8.5 | 6.6 |
Transmittance | T550nm≥99.0% | 99.8% |
Absorbance | A280nm≤0.25 | 0.15 |
Loss on drying | ≤10.0% | 5.9% |
Glucuronic acid | ≥45.0% | 47.6% |
Sodium hyaluronate | ≥93.0% | 98.4% |
Molecular weight, Dalton | measured value | 2.0*106 Dalton |
Intrinsic viscosity | measured value | 29.6dL/g |
Kinematic viscosity | measured value | 64.6mm2/s |
Protein | ≤0.1% | 0.05% |
Heavy Metals | ≤20mg/kg | <10mg/kg |
Bacteria counts | ≤100cfu/g | Complied |
Mold & Yeast | ≤50cfu/g | Complied |
Staphylococcus aureus | Negative/g | Negative |
Pseudomonas aeruginosa | Negative/g | Negative |
Test Items | Specification | Test Result |
Appearance | White or almost white powder or granule | Complied |
PH(1% water solution) | 5.0~8.5 | 6.5 |
Transmittance | T550nm≥99.0% | 99.9% |
Absorbance | A280nm≤0.25 | 0.11 |
Loss on drying | ≤10.0% | 7.0% |
Glucuronic acid | ≥45.0% | 47.4% |
Sodium hyaluronate | ≥93.0% | 98.1% |
Molecular weight, Dalton | measured value | 1.00*106 Dalton |
Intrinsic viscosity | measured value | 17.2dL/g |
Kinematic viscosity | measured value | 34.0mm2/s |
Protein | ≤0.1% | 0.04% |
Heavy Metals | ≤20mg/kg | <10mg/kg |
Bacteria counts | ≤100cfu/g | Complied |
Mold & Yeast | ≤50cfu/g | Complied |
Staphylococcus aureus | Negative/g | Negative |
Pseudomonas aeruginosa | Negative/g | Negative |
Test Items | Specification | Test Result |
Appearance | White or almost white powder or granule | Complied |
PH(1% water solution) | 5.0~8.5 | 6.5 |
Transmittance | T550nm≥99.0% | 99.9% |
Absorbance | A280nm≤0.25 | 0.07 |
Loss on drying | ≤10.0% | 6.9% |
Glucuronic acid | ≥45.0% | 46.4% |
Sodium hyaluronate | ≥93.0% | 96.1% |
Molecular weight, Dalton | measured value | 1.0*105 Dalton |
Intrinsic viscosity | measured value | 2.86dL/g |
Kinematic viscosity | measured value | 2.32mm2/s |
Protein | ≤0.1% | 0.05% |
Heavy Metals | ≤20mg/kg | <20mg/kg |
Bacteria counts | ≤100cfu/g | Complied |
Mold & Yeast | ≤50cfu/g | Complied |
Staphylococcus aureus | Negative/g | Negative |
Pseudomonas aeruginosa | Negative/g | Negative |
Test Items | Specification | Test Result |
Appearance | White or almost white powder or granule | Complied |
PH(1% water solution) | 5.0~8.5 | 6.6 |
Transmittance | T550nm≥99.0% | 99.9% |
Absorbance | A280nm≤0.25 | 0.05 |
Loss on drying | ≤10.0% | 6.5% |
Glucuronic acid | ≥45.0% | 47.0% |
Sodium hyaluronate | ≥93.0% | 97.2% |
Molecular weight, Dalton | measured value | 1.0*104 Dalton |
Intrinsic viscosity | measured value | 0.47dL/g |
Kinematic viscosity | measured value | 1.05mm2/s |
Protein | ≤0.1% | 0.03% |
Heavy Metals | ≤20mg/kg | <10mg/kg |
Bacteria counts | ≤100cfu/g | Complied |
Mold & Yeast | ≤50cfu/g | Complied |
Staphylococcus aureus | Negative/g | Negative |
Pseudomonas aeruginosa | Negative/g | Negative |
Product | Sodium hyaluronate | Grade | HA-E3.0 | ||
Batch No. | 22062201 | Batch size | 40.76kg | ||
Intrinsic viscosity | 2.7~3.6 m^3/kg | Production date | 2022.06.19 | ||
Standard | Ph.Eur.10.0 | Expiry date | 2025.06.19 | ||
Items | Acceptance criteria | Results | |||
Characters | White or almost white powder or fibrous aggregate | White powder | |||
Identification
| Consistent with the reference substance spectrum of sodium hyaluronate Positive | Complies Positive | |||
Appearance of solution | Clear A600nm≤0.01 | Clear 0.00 | |||
pH | 5.0~8.5 | 6.6 | |||
Intrinsic viscosity | 2.7~3.6 m^3/kg | 3.27 m^3/kg | |||
Nucleic acids | A260nm≤0.5 | 0.01 | |||
Protein | ≤0.1% | <0.0004% | |||
Chlorides | ≤0.5% | <0.5% | |||
Iron | ≤30 ppm | <2 ppm | |||
Loss on drying | ≤20.0% | 13.1% | |||
Microbial contamination (TAMC) | ≤100 cfu/g | <20 cfu/g | |||
Bacterial Endotoxins | <0.5 IU/mg | <0.5 IU/mg | |||
Residual solvents (Ethanol) | ≤5000 ppm | <24 ppm | |||
Formaldehyde | ≤100 ppm | 10 ppm | |||
Assay | 95.0%~105.0%(dried substance) | 100.1% |
Product | Sodium hyaluronate | Grade | HA-EP1.8 | ||
Batch No. | 22051311 | Batch size | 6.370kg | ||
Intrinsic viscosity | 1.6~2.2 m^3/kg | Production date | 2022.05.14 | ||
Standard | Ph.Eur.10.0 | Expiry date | 2025.05.14 | ||
Items | Acceptance criteria | Results | |||
Characters | White or almost white powder or fibrous aggregate | White powder | |||
Identification
| Consistent with the reference substance spectrum of sodium hyaluronate Positive | Complies Positive | |||
Appearance of solution | Clear A600nm≤0.01 | Clear 0.00 | |||
pH | 5.0~8.5 | 6.2 | |||
Intrinsic viscosity | 1.6~2.2 m^3/kg | 1.85 m^3/kg | |||
Nucleic acids | A260nm≤0.5 | 0.01 | |||
Protein | ≤0.1% | <0.0004% | |||
Chlorides | ≤0.5% | <0.5% | |||
Iron | ≤30 ppm | 2 ppm | |||
Loss on drying | ≤15.0% | 9.2% | |||
Microbial contamination (TAMC) | ≤100 cfu/g | <20 cfu/g | |||
Bacterial Endotoxins | <0.05 IU/mg | <0.05 IU/mg | |||
Residual solvents (Ethanol) | ≤5000 ppm | <186 ppm | |||
Residual solvents (Methanol) | ≤300 ppm | <32 ppm | |||
Formaldehyde | ≤50 ppm | <5.2 ppm | |||
Assay | 95.0%~105.0%(dried substance) | 100.2% |
Product | Sodium hyaluronate | Grade | HA-EP-N 2.5 | ||
Batch No. | 22022501 | Batch size | 40.84kg | ||
Intrinsic viscosity | 2.2~3.0 m^3/kg | Production date | 2022.02.22 | ||
Standard | Ph.Eur.10.0 | Expiry date | 2025.02.22 | ||
Items | Acceptance criteria | Results | |||
Characters | White or almost white powder or fibrous aggregate | White powder | |||
Identification
| Consistent with the reference substance spectrum of sodium hyaluronate Positive | Complies Positive | |||
Appearance of solution | Clear A600nm≤0.01 | Clear 0.00 | |||
pH | 5.5~7.0 | 6.4 | |||
Intrinsic viscosity | 2.2~3.0 m^3/kg | 2.45 m^3/kg | |||
Nucleic acids | A260nm≤0.1 | 0.01 | |||
Protein | ≤0.1% | <0.0004% | |||
Chlorides | ≤0.1% | <0.1% | |||
Iron | ≤20 ppm | 4 ppm | |||
Loss on drying | ≤10.0% | 7.2% | |||
Microbial contamination TAMC TYMC | ≤100 cfu/g ≤100 cfu/g | <20 cfu/g <20 cfu/g | |||
Bacterial Endotoxins | <0.04 IU/mg | <0.04 IU/mg | |||
Residual solvents (Ethanol) | ≤5000 ppm | <24 ppm | |||
Assay | 95.0%~105.0%(dried substance) | 99.6% |
Product | Sodium hyaluronate | Grade | HA-EP-N 1.8 | ||
Batch No. | 22020402 | Batch size | 41.63kg | ||
Intrinsic viscosity | 1.6~2.2 m^3/kg | Production date | 2022.02.01 | ||
Standard | Ph.Eur.10.0 | Expiry date | 2025.02.01 | ||
Items | Acceptance criteria | Results | |||
Characters | White or almost white powder or fibrous aggregate | White powder | |||
Identification
| Consistent with the reference substance spectrum of sodium hyaluronate Positive | Complies Positive | |||
Appearance of solution | Clear A600nm≤0.01 | Clear 0.00 | |||
pH | 5.5~7.0 | 6.5 | |||
Intrinsic viscosity | 1.6~2.2 m^3/kg | 1.84 m^3/kg | |||
Nucleic acids | A260nm≤0.1 | 0.01 | |||
Protein | ≤0.1% | <0.0004% | |||
Chlorides | ≤0.1% | <0.1% | |||
Iron | ≤20 ppm | 7 ppm | |||
Loss on drying | ≤10.0% | 7.9% | |||
Microbial contamination TAMC TYMC | ≤100 cfu/g ≤100 cfu/g | <20 cfu/g <20 cfu/g | |||
Bacterial Endotoxins | <0.04 IU/mg | <0.04 IU/mg | |||
Residual solvents (Ethanol) | ≤5000 ppm | <26 ppm | |||
Assay | 95.0%~105.0%(dried substance) | 100.2% |
Baoding Faithful Industry Co., Ltd. was established in 2005 and is located in the National High Tech Industrial Science and Technology Park of Baoding City, Hebei Province. It specializes in researching, producing, and selling raw materials for health products. Its main products include sodium hyaluronate, collagen, trypsin, gastric enzymes, and plant extracts. Our products are exported to over 20 countries, including the Americas, Europe, and Asia. We have extensive markets and research centers in the United States, Germany, Japan, and other places and a vast database of cutting-edge skin biology that accurately captures global trends. The laboratory has senior engineers and high-end experimental equipment, pursuing ultimate scientificity and safety and meeting consumers' high requirements for quality of life. We have established a comprehensive service system from quality control and sales to after-sales service and have passed the ISO9001 quality management system. We will provide new and old cosmetics customers with higher quality products, higher quality, more complete, and more thoughtful services.