Carbetocin, CAS No: 37025-55-1, Pharmaceutical Peptide

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Product origin: Hangzhou, Zhejiang, China
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US$ 800 ~ 1000

Description

   

Product Description

 Carbetocin, an oxytocin (OT) analogue, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin has high affinity to chimeric N-terminus (E1) of the oxytocin receptor (Ki=1.17 μM). Carbetocin has the potential for postpartum hemorrhage research. Carbetocin can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS.

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Product Parameters

 

Product Introduction
 
Generic name  Carbetocin
Formula  C45H69N11O12S
CAS No.  37025-55-1
Molecular Weight   988.17
EINECS  253-312-6

  Chemical Properties
Density  1.218±0.06 g/cm3(Predicted)
Melting Point  140 - 160°C
Boling Point  1477.9±65.0 °C(Predicted)
Solubility 
Soluble in water, 1% acetic acid
Specific Rotation(α)  D -69.0° (c = 0.25 in 1M acetic acid)
Refractive Index  1.541
Storage Condition  -15°C
pka  13.07±0.70(Predicted)
Apperance  White to beige powder

Application & Efficacy

      After intravenous or intramuscular injection of carbetocin, the uterus contracts rapidly and can reach a definite strength within 2 minutes. The active effect of a single dose of intravenous carbetocin on the uterus can last about 1 hour, so it is sufficient to prevent postpartum hemorrhage just after birth. After giving carbetocin after delivery, the frequency and amplitude of contraction are longer than oxytocin.
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