High Quality Food Grade White Powder Sodium Hyaluronate Hyaluronic Acid 9067-32-7

Min.Order: 10

Product origin: Hangzhou, Zhejiang, China

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US$ 100

Description

Product Description

Product Introduction

What is Sodium Hyaluronate?

Sodium hyaluronate is a salt form of hyaluronic acid, a naturally occurring substance in the body. It belongs to the glycosaminoglycan family of carbohydrates and comprises repeating disaccharide units of N-acetylglucosamine and glucuronic acid. It is commonly used in the medical and cosmetic industries.

The sources of sodium hyaluronate can be both animal and bacterial. In the past, it was commonly extracted from rooster combs. Still, it is more widely produced through bacterial fermentation, where bacteria are genetically modified to produce high yields of hyaluronic acid.

Sodium hyaluronate has many uses in the medical field and cosmetics. In medicine, it is used to treat joint disorders such as osteoarthritis, as well as for eye surgery and wound healing. In cosmetics, it is used as a moisturizer and skin conditioner to improve skin texture and elasticity and reduce wrinkles. It can also be found in topical skincare products such as serums, creams, and masks. Additionally, it is used in some injectable dermal fillers to enhance facial features and restore volume loss.

What Can We Supply?

Injection Grade(Medical Grade)Sodium Hyaluronate

Eye Drop Grade(Medical Grade)Sodium Hyaluronate

Cosmetic Grade Sodium Hyaluronate

Food Grade Sodium Hyaluronate

Application

The Application of Sodium Hyaluronate

Dermal Fillers: Sodium hyaluronate is used in injectable dermal fillers to help restore volume to areas of the face that have lost fat or collagen. Dermal fillers containing sodium hyaluronate are injected into the skin, where they add volume and smooth out wrinkles and fine lines. The effects of these fillers typically last several months to a year, depending on the product and the individual.

Wound Healing: Sodium hyaluronate is used in wound healing as a dressing or spray. It helps to keep the wound moist and prevent the formation of scabs, which can impede recovery. Sodium hyaluronate is also believed to have anti-inflammatory properties, which can help to reduce pain and swelling associated with wounds.

Drug Delivery: Sodium hyaluronate is being investigated as a drug delivery vehicle for various drugs, including chemotherapy. The large size of the sodium hyaluronate molecule makes it ideal for encapsulating drugs and delivering them to specific tissues or cells. Sodium hyaluronate can also help prolong drug release, making them more effective.

Function

The Function of Sodium Hyaluronate

Sodium hyaluronate has various functions, from moisturizing and lubricating tissues to reducing inflammation and promoting tissue regeneration. Its unique properties make it a valuable ingredient in many products and treatments.

Hydration: One of the main functions of sodium hyaluronate is to hydrate the skin or other tissues. Sodium hyaluronate can hold up to 1,000 times its weight in water, making it an excellent moisturizer. When applied to the skin or injected into tissues, sodium hyaluronate helps to restore moisture and improve skin or tissue hydration.

Lubrication: Sodium hyaluronate also has lubricating properties, particularly in joints. It helps to reduce friction between joint surfaces and improve joint mobility. This makes it beneficial in joint injections for conditions such as osteoarthritis.

Anti-inflammatory: Sodium hyaluronate has been found to have anti-inflammatory properties, which can help to reduce pain and swelling. It is thought to inhibit the production of pro-inflammatory cytokines and enzymes, reducing inflammation.

Tissue Regeneration: Sodium hyaluronate has been found to stimulate tissue regeneration in various tissues, including skin and bone. It can help to promote the growth of new cells and tissues, leading to faster healing and tissue repair.

Anti-aging: Sodium hyaluronate is a popular ingredient in anti-aging skincare products due to its ability to improve hydration and reduce the appearance of fine lines and wrinkles. It helps plump the skin and improve skin elasticity, leading to a more youthful appearance.

Specification

Molecular Structure of Sodium Hyaluronate

Specification Standards for Sodium Hyaluronate

Food grade: Sodium hyaluronate can be used in the food industry as a thickener, stabilizer, and emulsifier. It is used in baked goods, sauces, and dressings. Food-grade sodium hyaluronate should meet specific purity and quality standards the food industry sets.

1. High Molecular Weight (HMW) Sodium Hyaluronate

Test Items	Specification	Test Result
Appearance	White or almost white powder or granule	Complied
PH(1% water solution)	5.0~8.5	7.1
Transmittance	T_550nm≥99.0%	99.8%
Absorbance	A_280nm≤0.25	0.15
Loss on drying	≤10.0%	6.4%
Glucuronic acid	≥45.0%	47.16%
Sodium hyaluronate	≥93.0%	97.50%
Molecular weight, Dalton	measured value	2.0*10⁶Dalton
Intrinsic viscosity	measured value	29.6dL/g
Kinematic viscosity	measured value	64.6mm²/s
Protein	≤0.1%	0.05%
Heavy Metals	≤20mg/kg	<10mg/kg
Bacteria counts	≤100cfu/g	Complied
Mold & Yeast	≤50cfu/g	Complied
Staphylococcus aureus	Negative/g	Negative
Pseudomonas aeruginosa	Negative/g	Negative

2. Medium Molecular Weight (MMW) Sodium Hyaluronate

Test Items	Specification	Test Result
Appearance	White or almost white powder or granule	Complied
PH	6.0~8.0	6.7
Transmittance	T_600nm≥99.0%	99.8%
Loss on drying	≤10.0%	6.4%
Glucuronic acid	≥44.5%	47.2%
Sodium hyaluronate	≥92.0%	97.6%
Molecular weight, Dalton	measured value	1.00*10⁶Dalton
Intrinsic viscosity	measured value	17.1dL/g
The bulk density	measured value	0.32g/cm³
The tap density	measured value	0.49g/cm³
Protein	<0.1%	0.05%
Ash	≤13.0%	<13.0%
Heavy Metal(as Pb)	≤10mg/kg	<10mg/kg
Arsenic	≤2mg/kg	<2mg/kg
Bacteria counts	≤100cfu/g	Complied
Mold & Yeast	≤50cfu/g	Complied
Staphylococcus aureus	Negative/g	Negative
Escherichia coli	Negative/g	Negative
Salmonella	Negative/25g	Negative

3. Low Molecular Weight (LMW) Sodium Hyaluronate

Test Items	Specification	Test Result
Appearance	White or almost white powder or granule	Complied
PH(1% water solution)	5.0~8.5	7.0
Transmittance	T_550nm≥99.0%	99.8%
Absorbance	A_280nm≤0.25	0.17
Loss on drying	≤10.0%	7.4%
Glucuronic acid	≥45.0%	47.21%
Sodium hyaluronate	≥93.0%	97.6%
Molecular weight, Dalton	measured value	2.0*10⁵Dalton
Intrinsic viscosity	measured value	4.91dL/g
Kinematic viscosity	measured value	4.61mm²/s
Protein	≤0.1%	0.05%
Heavy Metals	≤20mg/kg	<10mg/kg
Bacteria counts	≤100cfu/g	Complied
Mold & Yeast	≤50cfu/g	Complied
Staphylococcus aureus	Negative/g	Negative
Pseudomonas aeruginosa	Negative/g	Negative

4. Very Low Molecular Weight (VLMW) Sodium Hyaluronate

Test Items	Specification	Test Result
Appearance	White or almost white, very hygroscopic powder or fibrous aggregate	Complied
PH(1% water solution)	5.0~8.5	7.0
Solubility	Sparingly soluble or soluble in water, practically insoluble in acetone and in anhydrous ethanol	Complied
Identification	A. Infrared absorption spectrophotometry	Complied
Identification	B. It gives reaction (a) of sodium	Complied
Loss on drying	≤10.0%	5.7%
Sodium hyaluronate	≥95.0%	97.0%
Appearance of solution	A_600nm≤0.01	Complied
Nucleic acids	A_260nm≤0.5	Complied
Molecular weight, Dalton	measured value	10,000 Dalton
Intrinsic viscosity	measured value	0.19dL/g
Protein	≤0.1%	0.06%
Chlorides	≤0.5%	Complied
Iron	≤80ppm	<80ppm
TAMC	≤100cfu/g	Complied
Staphylococcus aureus	Negative/g	Negative
Pseudomonas aeruginosa	Negative/g	Negative

Cosmetic grade: Sodium hyaluronate is a popular ingredient in cosmetics and personal care products due to its moisturizing and anti-aging properties. As mentioned in my previous answer, cosmetic-grade sodium hyaluronate should meet certain specifications regarding its molecular weight, purity, and degree of cross-linking.

1. High Molecular Weight (HMW) Sodium Hyaluronate

Test Items	Specification	Test Result
Appearance	White or almost white powder or granule	Complied
PH(1% water solution)	5.0~8.5	6.6
Transmittance	T_550nm≥99.0%	99.8%
Absorbance	A_280nm≤0.25	0.15
Loss on drying	≤10.0%	5.9%
Glucuronic acid	≥45.0%	47.6%
Sodium hyaluronate	≥93.0%	98.4%
Molecular weight, Dalton	measured value	2.0*10⁶Dalton
Intrinsic viscosity	measured value	29.6dL/g
Kinematic viscosity	measured value	64.6mm²/s
Protein	≤0.1%	0.05%
Heavy Metals	≤20mg/kg	<10mg/kg
Bacteria counts	≤100cfu/g	Complied
Mold & Yeast	≤50cfu/g	Complied
Staphylococcus aureus	Negative/g	Negative
Pseudomonas aeruginosa	Negative/g	Negative

2. Medium Molecular Weight (MMW) Sodium Hyaluronate

Test Items	Specification	Test Result
Appearance	White or almost white powder or granule	Complied
PH(1% water solution)	5.0~8.5	6.5
Transmittance	T_550nm≥99.0%	99.9%
Absorbance	A_280nm≤0.25	0.11
Loss on drying	≤10.0%	7.0%
Glucuronic acid	≥45.0%	47.4%
Sodium hyaluronate	≥93.0%	98.1%
Molecular weight, Dalton	measured value	1.00*10⁶Dalton
Intrinsic viscosity	measured value	17.2dL/g
Kinematic viscosity	measured value	34.0mm²/s
Protein	≤0.1%	0.04%
Heavy Metals	≤20mg/kg	<10mg/kg
Bacteria counts	≤100cfu/g	Complied
Mold & Yeast	≤50cfu/g	Complied
Staphylococcus aureus	Negative/g	Negative
Pseudomonas aeruginosa	Negative/g	Negative

3. Low Molecular Weight (LMW) Sodium Hyaluronate

Test Items	Specification	Test Result
Appearance	White or almost white powder or granule	Complied
PH(1% water solution)	5.0~8.5	6.5
Transmittance	T_550nm≥99.0%	99.9%
Absorbance	A_280nm≤0.25	0.07
Loss on drying	≤10.0%	6.9%
Glucuronic acid	≥45.0%	46.4%
Sodium hyaluronate	≥93.0%	96.1%
Molecular weight, Dalton	measured value	1.0*10⁵Dalton
Intrinsic viscosity	measured value	2.86dL/g
Kinematic viscosity	measured value	2.32mm²/s
Protein	≤0.1%	0.05%
Heavy Metals	≤20mg/kg	<20mg/kg
Bacteria counts	≤100cfu/g	Complied
Mold & Yeast	≤50cfu/g	Complied
Staphylococcus aureus	Negative/g	Negative
Pseudomonas aeruginosa	Negative/g	Negative

4. Very Low Molecular Weight (VLMW) Sodium Hyaluronate

Test Items	Specification	Test Result
Appearance	White or almost white powder or granule	Complied
PH(1% water solution)	5.0~8.5	6.6
Transmittance	T_550nm≥99.0%	99.9%
Absorbance	A_280nm≤0.25	0.05
Loss on drying	≤10.0%	6.5%
Glucuronic acid	≥45.0%	47.0%
Sodium hyaluronate	≥93.0%	97.2%
Molecular weight, Dalton	measured value	1.0*10⁴Dalton
Intrinsic viscosity	measured value	0.47dL/g
Kinematic viscosity	measured value	1.05mm²/s
Protein	≤0.1%	0.03%
Heavy Metals	≤20mg/kg	<10mg/kg
Bacteria counts	≤100cfu/g	Complied
Mold & Yeast	≤50cfu/g	Complied
Staphylococcus aureus	Negative/g	Negative
Pseudomonas aeruginosa	Negative/g	Negative

Medical grade: Sodium hyaluronate can also be used in various medical applications, such as joint injections for the treatment of osteoarthritis, as well as in wound healing and tissue regeneration. Medical-grade sodium hyaluronate must meet specific purity, molecular weight, and viscosity requirements as set by regulatory agencies such as the FDA in the United States and the European Medicines Agency (EMA) in Europe.

1. Eyedrop Grade Sodium Hyaluronate HA-E3.0

Product	Sodium hyaluronate		Grade		HA-E3.0
Batch No.	22062201		Batch size		40.76kg
Intrinsic viscosity	2.7~3.6 m^3/kg		Production date		2022.06.19
Standard	Ph.Eur.10.0		Expiry date		2025.06.19
Items		Acceptance criteria		Results
Characters		White or almost white powder or fibrous aggregate		White powder
Identification Infrared absorption Reaction of sodium		Consistent with the reference substance spectrum of sodium hyaluronate Positive		Complies Positive
Appearance of solution		Clear A600nm≤0.01		Clear 0.00
pH		5.0~8.5		6.6
Intrinsic viscosity		2.7~3.6 m^3/kg		3.27 m^3/kg
Nucleic acids		A260nm≤0.5		0.01
Protein		≤0.1%		<0.0004%
Chlorides		≤0.5%		<0.5%
Iron		≤30 ppm		<2 ppm
Loss on drying		≤20.0%		13.1%
Microbial contamination (TAMC)		≤100 cfu/g		<20 cfu/g
Bacterial Endotoxins		<0.5 IU/mg		<0.5 IU/mg
Residual solvents (Ethanol)		≤5000 ppm		<24 ppm
Formaldehyde		≤100 ppm		10 ppm
Assay		95.0%~105.0%(dried substance)		100.1%

2. Injection Grade Sodium Hyaluronate HA-EP1.8

Product	Sodium hyaluronate		Grade		HA-EP1.8
Batch No.	22051311		Batch size		6.370kg
Intrinsic viscosity	1.6~2.2 m^3/kg		Production date		2022.05.14
Standard	Ph.Eur.10.0		Expiry date		2025.05.14
Items		Acceptance criteria		Results
Characters		White or almost white powder or fibrous aggregate		White powder
Identification Infrared absorption Reaction of sodium		Consistent with the reference substance spectrum of sodium hyaluronate Positive		Complies Positive
Appearance of solution		Clear A600nm≤0.01		Clear 0.00
pH		5.0~8.5		6.2
Intrinsic viscosity		1.6~2.2 m^3/kg		1.85 m^3/kg
Nucleic acids		A260nm≤0.5		0.01
Protein		≤0.1%		<0.0004%
Chlorides		≤0.5%		<0.5%
Iron		≤30 ppm		2 ppm
Loss on drying		≤15.0%		9.2%
Microbial contamination (TAMC)		≤100 cfu/g		<20 cfu/g
Bacterial Endotoxins		<0.05 IU/mg		<0.05 IU/mg
Residual solvents (Ethanol)		≤5000 ppm		<186 ppm
Residual solvents (Methanol)		≤300 ppm		<32 ppm
Formaldehyde		≤50 ppm		<5.2 ppm
Assay		95.0%~105.0%(dried substance)		100.2%

3. Injection Grade Sodium Hyaluronate HA-EP-N 2.5

Product	Sodium hyaluronate		Grade		HA-EP-N 2.5
Batch No.	22022501		Batch size		40.84kg
Intrinsic viscosity	2.2~3.0 m^3/kg		Production date		2022.02.22
Standard	Ph.Eur.10.0		Expiry date		2025.02.22
Items		Acceptance criteria		Results
Characters		White or almost white powder or fibrous aggregate		White powder
Identification Infrared absorption Reaction of sodium		Consistent with the reference substance spectrum of sodium hyaluronate Positive		Complies Positive
Appearance of solution		Clear A600nm≤0.01		Clear 0.00
pH		5.5~7.0		6.4
Intrinsic viscosity		2.2~3.0 m^3/kg		2.45 m^3/kg
Nucleic acids		A260nm≤0.1		0.01
Protein		≤0.1%		<0.0004%
Chlorides		≤0.1%		<0.1%
Iron		≤20 ppm		4 ppm
Loss on drying		≤10.0%		7.2%
Microbial contamination TAMC TYMC		≤100 cfu/g ≤100 cfu/g		<20 cfu/g <20 cfu/g
Bacterial Endotoxins		<0.04 IU/mg		<0.04 IU/mg
Residual solvents (Ethanol)		≤5000 ppm		<24 ppm
Assay		95.0%~105.0%(dried substance)		99.6%

4. Injection Grade Sodium Hyaluronate HA-EP-N 1.8

Product	Sodium hyaluronate		Grade		HA-EP-N 1.8
Batch No.	22020402		Batch size		41.63kg
Intrinsic viscosity	1.6~2.2 m^3/kg		Production date		2022.02.01
Standard	Ph.Eur.10.0		Expiry date		2025.02.01
Items		Acceptance criteria		Results
Characters		White or almost white powder or fibrous aggregate		White powder
Identification Infrared absorption Reaction of sodium		Consistent with the reference substance spectrum of sodium hyaluronate Positive		Complies Positive
Appearance of solution		Clear A600nm≤0.01		Clear 0.00
pH		5.5~7.0		6.5
Intrinsic viscosity		1.6~2.2 m^3/kg		1.84 m^3/kg
Nucleic acids		A260nm≤0.1		0.01
Protein		≤0.1%		<0.0004%
Chlorides		≤0.1%		<0.1%
Iron		≤20 ppm		7 ppm
Loss on drying		≤10.0%		7.9%
Microbial contamination TAMC TYMC		≤100 cfu/g ≤100 cfu/g		<20 cfu/g <20 cfu/g
Bacterial Endotoxins		<0.04 IU/mg		<0.04 IU/mg
Residual solvents (Ethanol)		≤5000 ppm		<26 ppm
Assay		95.0%~105.0%(dried substance)		100.2%

It's important to note that these grades of sodium hyaluronate are not interchangeable, and a product intended for one use may not be suitable for another use. For example, food-grade sodium hyaluronate should not be used in medical or cosmetic applications, as it may not meet the necessary purity or quality standards. Similarly, medical-grade sodium hyaluronate should not be used in food products, as it may be unsafe for ingestion.

The Production Process of Sodium Hyaluronate

The production process of sodium hyaluronate is a complex and multi-step process involving fermentation, precipitation, filtration, and drying. The final product is a high-purity powder that can be used in various applications, from skincare products to medical treatments.

Preparation of Fermentation Medium: The fermentation medium is prepared by dissolving glucose and yeast powder in water and adding magnesium sulfate and sodium hydroxide. The solution is sterilized by autoclaving to ensure no bacteria or other contaminants are present.

Fermentation: The sterilized fermentation medium is then inoculated with a hyaluronic acid-producing bacterial strain, and the fermentation process can proceed for several days. During this time, the bacteria convert the glucose in the medium into hyaluronic acid monomers through metabolic conversion. The bacteria grow and multiply, producing more and more hyaluronic acid.

Precipitation and Centrifuge Separation: Once the fermentation process is complete, the hyaluronic acid is harvested from the broth. This is done by adding a salt solution to the broth, which causes the hyaluronic acid to precipitate out of the solution. The precipitated hyaluronic acid is then separated from the broth by centrifugation.

Crude Polymer Sodium Hyaluronate: The resulting material is a crude polymer of sodium hyaluronate, which still contains impurities and other substances. This material is dissolved in water and filtered to remove any remaining particulates or contaminants.

Twice-Precipitation: The filtered solution of sodium hyaluronate is then subjected to a process known as twice-precipitation. This involves adding a specific type and amount of salt to the solution, which causes the hyaluronic acid to precipitate out of the key again. The precipitated hyaluronic acid is separated from the solution by centrifugation, and this process is repeated to ensure that the final product is as pure as possible.

Drying and Packing: The purified hyaluronic acid is then dried using a spray dryer, which removes any remaining moisture from the product. The dried powder is then packed into containers for storage and shipment.

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