ISO Factory Top Quality Gts21 Gts-21 Dmxb-a Powder CAS 156223-05-1

Min.Order: 10
Product origin: Wuhan, Hubei, China
Infringement complaint: complaintComplaint
US$ 1 ~ 5

Description
ISO Factory Top Quality GTS21 GTS-21 DMXB-A Powder CAS 156223-05-1

Basic Information:
 
 
Product Name: Gts-21 Dmbx-Anabaseine
Purity: 99%min by HPLC
CAS No.: 156223-05-1
Appearance: White powder
M.W.: 308.374
M.F.: C19H20N2O2

GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation. Target: nAChRin vitro: GTS-21 is one of the most potent α7nAChR agonists, has been reported to attenuate pro-inflammatory cytokine production, improve outcomes in sepsis models, pancreatitis, and ischemia-reperfusion injury, and inhibit the production of endotoxin-induced TNF in lung tissue. In addition, recent studies have demonstrated that GTS-21 inhibits the activities of endothelial cells and monocyte macrophages, as well as the secretion of pro-inflammatory cytokines in peripheral blood samples, by regulating the JAK2-STAT3 pathway. [1] in vivo: In septic animals, GTS-21 significantly ameliorated GI motility, lowered systemic and colonic levels of IL-6, decreased colonic permeability, and decreased the number of positive cultures obtained from blood and mesenteric lymph nodes. Splenectomy prevented animals from developing sepsis-induced ileus. Chrna7 mice displayed a more severe septic phenotype, whereas GTS-21 remarkably was also beneficial in these animals.








Product Tag:
Related categories:
Scroll to Top