Dipyridamole Raw Material CAS 58-32-2

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Product origin: Hefei, Anhui, China

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US$ 350 ~ 450

Description

Dipyridamole CAS 58-32-2

Product Name:	Dipyridamole
CAS:	58-32-2
MF:	C24H40N8O4
MW:	504.63
EINECS:	200-374-7
Mol File:	58-32-2.mol
Dipyridamole Chemical Properties
Melting point	165-166 °C (lit.)
Boiling point	593.96°C (rough estimate)
density	1.2046 (rough estimate)
refractive index	1.6910 (estimate)
storage temp.	room temp
solubility	DMSO: soluble
form	powder
pka	pKa 6.4 (Uncertain)
color	yellow
Water Solubility	Soluble in chloroform, methanol, dilute acids, ethanol. Slightly soluble in water.
Merck	143,346
NIST Chemistry Reference	Pyrimidine, 2,6-bis(diethanolamino)-4,8-dipiperidino-pyrimido-(5,4-d)-(58-32-2)

Dipyridamole, 2,2',2',2'''-[(4,8-di-1piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]-tetrakisethanol (Persantine), may be used for coronary andmyocardial insufficiency. Its biggest use today, however, isas an antithrombotic in patients with prosthetic heart valves.It is a bitter, yellow, crystalline powder, soluble in diluteacids, methanol, or chloroform. A formulation containingdipyridamole and aspirin (Aggrenox) is currently beingmarketed as an antithromobotic.

Dipyridamole is a long-acting vasodilator. Its vasodilatingaction is selective for the coronary system; it is indicatedfor long-term therapy of chronic angina pectoris. Thedrug also inhibits adenosine deaminase in erythrocytesand interferes with the uptake of the vasodilator adenosineby erythrocytes. These actions potentiate the effect ofprostacyclin (PGI2), which acts as an inhibitor to plateletaggregation.

Function
Dipyridamole, a coronary artery dilator and antithrombotic drug, is used mainly for ischemic heart disease and stroke, but to a lesser extent for other conditions.Its side effects may include headache, dizziness, nausea, vomiting, diarrhea and other adverse reactions. Combined with heparin, it may cause bleeding tendency, occasional rash, and coronary artery blood theft.Early years used to be the treatment of coronary heart disease drugs, now less used as an anti-myocardial ischemia.Its anti-platelet aggregation effect can be used in cardiac surgery or valve replacement, which can reduce the formation of thromboembolism.
Dipyridamole is a long-acting vasodilator. Its vasodilatingaction is selective for the coronary system; it is indicatedfor long-term therapy of chronic angina pectoris. Thedrug also inhibits adenosine deaminase in erythrocytesand interferes with the uptake of the vasodilator adenosineby erythrocytes. These actions potentiate the effect ofprostacyclin (PGI2), which acts as an inhibitor to plateletaggregation.

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