Pharmaceutical Raw Material Powder CAS 134523-03-8 Atorvastatin Calcium

Min.Order: 25
Product origin: Hefei, Anhui, China
Infringement complaint: complaintComplaint
US$ 200 ~ 300

Description
CAS 134523-03-8 Atorvastatin Calcium

CAS: 134523-03-8
MF: C66H68CaF2N4O10
MW: 1155.36
EINECS: 200-659-6
Melting point: 176-178°C
Storage temp.: Store at +4°C
Appearance: White Crystalline Powder


Specification
ItemsStandardResults
APPEARANCEOff white to white powderWhite powder
IDENTIFICATIONA: IR
B: Retention time
Complies
Complies
WATER0.5%0.06%
HEAVY METALS≤0.002%Complies
ISOMERSSFBD1≤0.15%Undetected
 SFBD2≤0.15%Undetected
 SFBE≤0.15%Undetected
RELATED SUBSTANCESSFBA-1≤0.15%0.04%
 SFBMA≤0.15%Undetected
 CHLORO-SFB≤0.15%0.05%
 DiSFBMA-SFB≤0.15%0.02%
 Methyl-SFB≤0.15%Undetected
 Pentafluoro-phenol≤0.15%Undetected
 Amino-SFB≤0.15%Undetected
 Any unknown impurity≤0.1%0.04%
 Total impurity≤1.0%0.21%
ASSAY≥99.0%99.8%
RESULT:  It complies to prescribed enterprise standard

Function
Lipitor was launched in Canada, the Netherlands, the UK and the US as an orally-active hypocholesterolemic agent.
It was the first pharmaceutical product ever to attain over one billion dollars in sales in its first year. It can be
synthesized by a number of routes but the most efficient involves the Paal-Knorr reaction of an acetonide protected
dihydroxy amino ester and a diaryl phenylacetamide diketone. Lipitor is a liver selective, reversible competitive
inhibitor of HMG-CoA reductase, the rate limiting step in cholesterol biosynthesis. Lipitor monotherapy resulted
in a reduction of LDL cholesterol by up to 60%. Lipitor is about 2-4 times more potent, on a dosage basis, than
Simvastatin.


Application
A selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated
for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia..

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