What is J147  Powder ?

J-147 is a particularly potent, orally active neuroprotector that enhances cognitive function. J-147 can cross the

blood-brain barrier (BBB). J-147 inhibited monoamine oxidase B(MAOB) and dopaminetransporter (dopaminetransporter)

with EC50 values of 1.88μM and 0.649μM, respectively. J-147 has potential to be used in Alzheimer's disease

(AD) research.


Application&Function

J147 is J-147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to

enhance memory in normal animals as well as to prevent memory deficits in Alzheimer's disease (AD) transgenic

mice.The neurotrophic and memory-enhancing activities of J-147 are associated with an increase in brain derived

neurotrophicfactor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the

preservation of synaptic protein, the reduction of amyloid plaques.