Anti -S100 Alpha 6/Pra Rabbit Primary Polyclonal Antibody

Min.Order: 1

Product origin: Wuhan, Hubei, China

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US$ 100 ~ 200

Description

Anti -S100 alpha 6/PRA Rabbit Primary Polyclonal Antibody

Product Information

Description	S100A6 rabbit polyclonal
Protein full name	Protein S100-A6
Synonyms	5B10, Calcyclin, Prolactin receptor-associated protein, S100 calcium-binding protein A6, S100a6, Cacy
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse S100A6
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cell membrane, Cytoplasm, Nucleus
Uniprot ID	P14069, P05964

Applications

Applications	IHC	IF
Species	Human, Mouse, Rat	Human, Mouse, Rat
Dilution	1: 1000-1: 2000	1: 1000-1: 2000
Positive tissue	colon, testis, skin	colon cancer, small intestine, lung, testis, skin

Background

Calcyclin, also known as Protein S100-A6, growth factor-inducible protein 2A9, S-100 calcium-binding protein A6 (S-100A6) or MLN 4, is a homodimeric member of the S-100 calcium-binding protein family whose expression is upregulated in proliferating and differentiating cells. It may function as calcium sensor and modulator, contributing to cellular calcium signaling.Calcyclin is inducible by growth factors and overexpressed in acute myeloid leukemias. It is expressed in a cell-specific manner in subpopulations of neurons and astrocytes and in epithelial cells and fibroblasts. Calcyclin is a specific target of S-100B protein in vivo. The binding of Calcyclin to S-100B is stabilized by S-100B-bound calcium and zinc. Calcyclin associates with both Annexin XI and CacyBP (calcyclin-binding protein). It functions to activate several processes along the calcium signal transduction pathway including the regulation of cell growth, proliferation, secretion and exocytosis.

Images

	Immunohistochemistry analysis of paraffin-embedded human colon using S100A6 (GB111078) at dilution of 1: 1000
	Immunohistochemistry analysis of paraffin-embedded mouse testis using S100A6 (GB111078) at dilution of 1: 1000
	Immunohistochemistry analysis of paraffin-embedded rat testis using S100A6 (GB111078) at dilution of 1: 1000
	Immunohistochemistry analysis of paraffin-embedded mouse skin using S100A6 (GB111078) at dilution of 1: 1000
	Immunohistochemistry analysis of paraffin-embedded rat skin using S100A6 (GB111078) at dilution of 1: 1000

Storage

Storage	Store at -20 ºC for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

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