Complaint
| Catalog No. | BS64546 |
|---|---|
| Product Name | PINK1 (Phospho-S402) polyclonal antibody |
| Applications | WB |
| Alternative Name | Serine/threonine-protein kinase PINK1, mitochondrial; BRPK; PTEN-induced putative kinase protein 1; PINK1 |
| Swiss-Prot | Q9BXM7 |
| Host | Rabbit |
| Reactivity | Human |
| Application_all | WB: 1:500~1:1000 IHC: 1:50~1:200 |
| Product | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
| Purification&Purity | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Storage&Stability | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Specificity | PINK1 (Phospho-S402) polyclonal antibody detects endogenous levels of PINK1 protein only when phosphorylated at Ser402. |
| BiowMW | ~ 60 kDa |
| Note | For research use only, not for use in diagnostic procedure. |
| Immunogen | Synthetic phosphopeptide derived from human PINK1 around the phosphorylation site of Serine 402. |
Background
PTEN induced putative kinase 1, PINK1, is a mitochondrial serine/threonine kinase involved in the normal function and integrity of mitochondria, as well as in reduction of cytochrome c release from mitochondria. PINK1 phosphorylates Parkin and promotes its translocation to mitochondria. Research studies have shown that mutations in PINK1 are linked to autosomal recessive early onset Parkinson's disease, and are associated with loss of protective function, mitochondrial dysfunction, aggregation of α-synuclein, as well as proteasome dysfunction.
