Complaint
| Catalog No. | BS65001 |
|---|---|
| Product Name | Lamin A/C (Phospho-S392) polyclonal antibody |
| Applications | WB IHC IF |
| Alternative Name | Prelamin-A/C; Lamin-A/C; Lamin A/C; LaminA/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32; LMNA; LMN1; Lamin A; LaminA; Lamin-A; Lamin C; LaminC; Lamin-C |
| Swiss-Prot | P02545 |
| Host | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Application_all | WB: 1:500~1:1000 IHC: 1:50~1:200 |
| Product | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
| Purification&Purity | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Storage&Stability | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Specificity | Lamin A/C (Phospho-S392) polyclonal antibody detects endogenous levels of Lamin A/C protein only when phosphorylated at Ser392. |
| BiowMW | ~ 74, 65 kDa |
| Note | For research use only, not for use in diagnostic procedure. |
| Immunogen | Synthetic phosphopeptide derived from human Lamin A/C around the phosphorylation site of Serine 392. |
Background
Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
