Complaint
| Catalog No. | BS3687 |
|---|---|
| Product Name | Neuropilin-2 (M373) polyclonal antibody |
| Applications | WB |
| Alternative Name | Neuropilin-2; Vascular endothelial cell growth factor 165 receptor 2; VEGF165R2; NRP2 |
| Swiss-Prot | O60462 |
| Host | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Application_all | WB: 1:500~1:1000 |
| Product | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
| Purification&Purity | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Storage&Stability | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Specificity | Neuropilin-2 (M373) polyclonal antibody detects endogenous levels of Neuropilin-2 protein. |
| BiowMW | ~92 kDa |
| Note | For research use only, not for use in diagnostic procedure. |
| Immunogen | Synthetic peptide, corresponding to amino acids 341-390 of Human Neuropilin-2. |
Background
Neuropilin is a type I transmembrane receptor that has been implicated in aspects of axon growth and guidance and has been shown to act as a high affinity receptor for class III semaphorins and vascular endothelial growth factor (VEGF). A closely related protein, neuropilin-2, shares a common domain structure and signifcant homology with neuropilin and also acts as a receptor for the class III semaphorins and VEGF. Both neuropilins are involved in regulating many physiological pathways including axonal guidance and angiogenesis, however they exhibit differential expression in the adult vasculature. Neuropilin-2 is polysialylated and expressed on the surface of dendritic cells. It is also expressed by venous and lymphatic endothelium. Neuropilin is expressed predominantly by arterial endothelium.
