Complaint
Product Information
| Description | COX2 rabbit polyclonal |
| Protein full name | Prostaglandin G/H synthase 2 |
Synonyms | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2, prostaglandin-endoperoxide synthase 2 |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse COX2 |
Isotype | IgG |
Purity | Affinity purification |
| Predicted MW. | 74KDa |
Observed MW. | 74KDa |
Uniprot ID | Q05769,P35355,P35354 |
Applications
| Applications | WB |
| Species | Human, Mouse, Rat |
Dilution | 1:1000 |
| Positive tissue | inflammatory lung, colon cancer, Raw264.7 |
Background
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.
Images
Western blot analysis of COX2 (GB11077-2) at dilution of 1:1000. Lane 1: Raw264.7 cell lysate Lane 2: B16 cell lysate Lane 3: Human colon cancer tissue lysate Lane 4: Mouse myeloma tissue lysate Lane 5: Mouse inflammatory lung tissue lysate Lane 6: Mouse brain tissue lysate Lane 7: Rat inflammatory lung tissue lysate Lane 8: Rat brain tissue lysate |
Storage
Storage | Store at -20 ºC for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
