Product Name:Gefitinib CAS:184475-35-2 MF:C22H24ClFN4O3 MW:446.9 EINECS:643-034-7 Mol File:184475-35-2.mol Melting point:119-1200C Boiling point:586.8±50.0 °C(Predicted) Density 1.322±0.06 g/cm3(Predicted) storage temp. Store at RT pka7.00±0.10(Predicted) form powder color white to beige
Description
Gefitinib is an antineoplastic target therapy drug with relatively high specificity that was developed by the British pharmaceutical company AstraZeneca; it is the first molecular targeted drug to be used in non-small cell lung cancer treatment. Epidermal growth factors (EGF) are a kind of polypeptide with a relative molecular mass of 6.45x103, and they can bind with epidermal growth factor receptors (EGFR) on target cell membrane surfaces to trigger biological effects. EGFR is a type of tyrosine kinase (TK) type receptor, so when bound with EGF, it will promote TK activation in the receptor. This will cause tyrosine residue in the receptor to autophosphorylate and send continuous dividing signals into the cell, causing cell proliferation and differentiation. EGFR is abundant in human tissue, and it is highly expressed in malign tumors. Gefitinib blocks the signal transduction pathway of cell surface EGFR to prevent tumor growth, metastasis, and growth in blood vessels, and it can induce tumor cell apoptosis. Gefitinib is mainly used to treat non-stem cell lung cancer.
GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient (API), biology, plant extracts, chemical raw materials, fine chemicals, pharmaceutical intermediates, cosmetics raw material. Our company has always adhered to the company phi osophy of integrity, professionalism, quality first, and customer service. With the efforts of all the company's employees, it has established long-term and stable cooperative relations with many domestic and foreign customers, and won the unanimous trust of domestic and foreign customers. With good comments, our company have made great progress.
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