Complaint
High Quality API 99% Powder Antipyrine
Antipyrine is an analgesic, a non-steroidal anti-inflammatory drug and an antipyretic.
Phenazone, also known as phenazon, antipyrine, or analgesine, is an analgesic, a non-steroidal anti-inflammatory drug and an antipyretic. It was first synthesized by Ludwig Knorr in 1883. It is formed by reducing diortho- dinitrodiphenyl with sodium amalgam and methyl alcohol, or by heating diphenylene-ortho-dihydrazine with hydrochloric acid to 150 °C. It crystallizes in needles which melt at 156 °C. Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid. Phenazone has an elimination half life of about 12 hours.
| Product Name | Antipyrine/Phenazone |
| Synonyms | 1,2-Dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one; 2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one; Phenazone |
| CAS No. | 60-80-0 |
| EINECS | 200-486-6 |
| Molecular Formula | C11H12N2O |
| Molecular Weight | 188.23 |
| Appearance | Colorless powder |
| Melting point | 109-113 ºC |
| Assay | 99% |
Item | Standard | Results |
Characteristics | Colorless or white crystal | conforms |
Melting Point | 110-113°C | 110.1-111.2°C |
Identification | Positive | Positive |
Chloride | Not more than 100ppm | conforms |
Sulphate | Not more than 100ppm | Conforms |
Sulphated Ash | Not more than 0.1% | Conforms |
Heavy Metals | Not More than 20ppm | <20ppm |
Colour of solution | Conforms | Conforms |
Acidic or Alkalinic Substances | Conforms | Conforms |
Loss on Drying | Not more than 1.0% | 0.2% |
Assay(On dry basis) | 99.0-100.5% | 99.7% |
Conclusion | Complies with BP2004 | |
