Pharmaceutical GMP Grade Agitated Nutsche Filter Dryer

Features

• The design and assembly of the equipment are carried out strictly following national GMP requirements, and fully conforming to pharmaceutical production process requirements. The system is safe, stable and reliable.

• The equipment materials are strictly controlled. The parts that directly contact materials are made of non-toxic and corrosion-resistant sealing material such as austenitic stainless steel(316L 304), Hastelloy, PTFE FFKM or EPDM etc. The filter screen adopts metal sintering screen made of SUS316L, C22 etc.

• The interior surfaces of the equipment that directly contact materials are flat and smooth without dead comer for the convenience of cleaning and sterilizing.

• The equipment dose not pollute the external environment. and the measures of dust prevention, leakage prevention, heat insulation and noise prevention are properly adopted. Under the fully closed working status, the motor, speed reducer and lifting device are protected by stainless steel outer covers, The retum duct in jacket adopts heat preservation cotton to insulate, can greatly reduce heat oss, heat exchange with the outside environment and the influence on the surroundings.

• Safe and reliable explosion-proof electrical appliances are adopted. The pulleys that can eliminate static electricity and other safe interlocks and safety devices are allocated.

• All the pipes of materials, solvents and nitrogen gas are designed to have no dead comer and blind pipe. The equipment surfaces are subjected to mechanical automatic fine polishing or electrolytic polishing with the interior surface Ras0 4 and the exterior surface Ra≤0.8.

• The blending shaft and lateral discharging valve stem are installed with metal bellows.

• 360 spraying cleaning spray balls for CIP are equipped in the tank. The balls can adopt 360-degree rotary spray ball.

• Dry-process double-face mechanical seal, nitrogen protection and cooling.

• Dust capture device with CIP function

Batch filtration-drying processes can be in the follow steps

1.Filling 

The vessel is filled with a slurry(liquid/solid mixture), generally fed from a reactor or crystallizing tank.

2.Filtration
A liquid/solid separation process takes place through the filtration media ,Filtration(solvent) are collected beneath the filter plate.

3.Piston displacement washing
Washing liquid are used to wash the product cake ,Avolume of liquid is displaced through the cake.washing it.

4.Reslurry washing
The agitator is used the re-slurry the solid in a washing solvent.

5.Smoothing
The agitator is used to smooth the wet cake in the filter dryer, to avoid the formation of cracks or preferential paths.

6.Drying and cooling
Agitated vacuum drying consists in applying a vacuum on the vessel, while heating the walls and agitator using thermal circuits.This allows to reach the liquid boiling point and to dry the product.

7.Discharging
The specially designed agitator pushes the product out towards a side discharge port.

Main parameters